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There is a better understanding of mental illness and the potential underlying mechanisms leading to new medications with novel mechanisms of action. The new medications seek to reduce side effects while optimizing efficacy. Attention-deficit hyperactivity disorder, mood disorders, movement disorders, neurocognitive disorders, psychotic disorders, sexual disorders, and sleep disorders have all had newly approved medications in the last 5 years. Some of the new indications are of older medications being explored for other indications. This article describes these medications, the trials supporting them, and relevant clinical information about each medication.

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