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September 2022Volume 2, Issue 1, Pages 29–36
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Neuropsychiatric Aspect of Posterior Cortical Atrophy

Chuang-Kuo Wu
x
Chuang-Kuo Wu
, MD, PhD
Department of Neurology, Brown University Alpert Medical School, Alzheimer’s Disease and Memory Disorders Center, Rhode Island Hospital, 593 Eddy Street, APC-7, Providence, RI 02903, USA
Neuropsychiatric Aspect of Posterior Cortical Atrophy
DOI: https://doi.org/10.1016/j.ypsc.2022.05.001
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Figures

Fig. 1

Drawing of the brain showing the anatomic landmarks for the posterior portion of brain.

Fig. 2

The evolution of posterior cortical atrophy in the sagittal view of brain MRI, comparing 2015 study with 2021 study.

Fig. 3

The test of copying the figures. Upper–normal control; lower–the patient’s copying.

Fig. 4

The test of copying the complex figure. (Left–the standard complex figure for copying; right–the patient’s drawing).

Fig. 5

The pattern of glucose hypometabolism in FDG-PET/CT brain. Upper panel shows decreased metabolism in occipital cortices (in yellow); lower panel shows a significant difference in occipital regions compared with normal control data base (in green).

Fig. 6

Positive results of Amyloid tracer–brain PET/CT study (left in the original image–a transverse view; right in the colored template focused on occipital regions–a coronal view).

First page of article

The clinical diagnosis of posterior cortical atrophy (PCA) has been established for more than 3 decades. Yet, this diagnostic entity only has obtained valuable academic attention in recent years. The cognitive profile of PCA is well documented and underlying pathology is extensively investigated. By contrast, the neuropsychiatric manifestation of PCA is rarely discussed in the medical literature. Based on the longitudinal observational study, this author has noted 3 stages or aspects of neuropsychiatric presentation of PCA through the disease course. More importantly, without effective treatment, neuropsychiatric symptoms play a major role in causing caregiver burden.

Keywords:

Atrophy, Dementia, Alzheimer, Hallucination, Anxiety, Depression, Lewy-body, Agnosia

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September 2022Volume 2, Issue 1, Pages 29–36