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September 2022Volume 2, Issue 1, Pages 37–46
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Psychedelics for Alzheimer's Disease Palliative Care

Kaitlin R. McManus
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Kaitlin R. McManus
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA

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  • Corresponding author. McLean Hospital, 115 Mill Street, Mailstop 234, Belmont, MA 02478.
, BAa,∗,'Correspondence information about the author BA Kaitlin R. McManus
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Kaitlin R. McManus
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA

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  • Corresponding author. McLean Hospital, 115 Mill Street, Mailstop 234, Belmont, MA 02478.
,
Regan Patrick
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Regan Patrick
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
  • Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
, PhDa,b
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Meg I. Striepe
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Meg I. Striepe
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  • California Institute of Integral Studies, 1453 Mission Street, San Francisco, CA 94103, USA
, PhDc
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Mia J. Drury
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Mia J. Drury
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
, BAa
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Rosain Ozonsi
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Rosain Ozonsi
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
, BSa
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Brent P. Forester
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Brent P. Forester
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
  • Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
, MD, MSca,b
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Marc S. Weinberg
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Marc S. Weinberg
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  • McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
  • Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
  • Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
, MD, PhDa,b,d
Psychedelics for Alzheimer's Disease Palliative Care
DOI: https://doi.org/10.1016/j.ypsc.2022.06.001
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Psychedelic compounds (psilocybin, lysergic acid diethylamide, ayahuasca) paired with psychotherapy offer great potential for addressing multiple aspects of unmet palliative care needs for aging patients with Alzheimer disease and their caregivers. In this review, the authors integrate recent findings from psychedelic and psychedelic-assisted therapy clinical research with key domains of Alzheimer disease palliative care, from neurobehavioral symptom management to social and spiritual aspects of care in patients and their caregivers. In doing so, they provide a framework for approaching use of these exciting compounds in the Alzheimer disease population, while recognizing some of the practical challenges faced.

Keywords:

Dementia, Psilocybin, LSD, Ayahuasca, Geriatric, Aging, Quality of life

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September 2022Volume 2, Issue 1, Pages 37–46